Medicare Drug Price Negotiation Program (MDPNP) Updates
Published: November 11, 2025
Updated: November 11, 2025
The Medicare Drug Price Negotiation Program (MDPNP) brings significant changes for pharmacies in 2026, including new contracting requirements with CMS and adjustments to Medicare Part D reimbursement rates for negotiated drugs. To help you prepare, IPC’s Government Relations team is linking resources to the MDPNP resource page with key details on enrollment, compliance, and contract review. Visit the CMS Dispensing Home Page for more to ensure your pharmacy is ready for these critical updates.
Additional Resources:
- CMS – Medicare Transaction Facilitator (MTF) Resources: Click Here
- CMS – Medicare Transaction Facilitator (MTF) Frequently Asked Questions: Click Here
- Review the MTF Data Module User Agreement: Click Here
- Verify your pharmacy NCPDP Profile is accurate and updated prior to starting the enrollment process: Click Here
- Phone: 1-877-MTF-4HLP (1-877-683-4457)
- Help Desk website (Includes ticket submission and live chat features): mtf.helpdesk.cms.gov
- MTF Toolkit: Click Here
Update: November 11, 2025
Information on the 10 Negotiated Drugs Rebate Program
CMS has released manufacturers’ effectuation plans for the Medicare Drug Price Negotiation Program. This plan will help to explain the process manufacturers are following to mitigate cashflow, provide estimate times to receive refunds and provide other information around the 10 IRA qualifying drugs.
To view this effectuation plan, click here: Download PDF
If you are not yet enrolled in the MTF, here is the process (Don’t Wait! Do it NOW!):
- Go to the CMS Enterprise Portal: The main access point is cms.gov.
- Log in or Create an Account:
- If your pharmacy already has an account for other CMS programs (like PECOS), use those existing credentials.
- If you are new to CMS systems, you will need to create a new account on the portal.
- Access the “Medicare Transaction Facilitator” Application: Once logged in, you will need to find and select the specific MTF application from your portal dashboard or menu to complete the enrollment process for your pharmacy.
Important Note: The “click here” link in the original text you provided is the most direct source for detailed enrollment instructions. It likely leads to a CMS.gov page with step-by-step guides and FAQs specifically for pharmacy enrollment in the MTF.
For the most current and official guidance, always refer to the CMS MTF Pharmacy Enrollment page, which can be found by searching for “Medicare Transaction Facilitator pharmacy enrollment” on cms.gov.
While details are still emerging, all manufacturers will use the free Beacon platform. Pharmacies must register with Beacon to access Maximum Fair Price (MFP) information, track refund claim status, and communicate with manufacturers. All manufacturers have elected to use the MTF Payment Module, which is believed to reduce administrative work for pharmacies. You will need to create an account with Beacon once you have finished enrolling in the MTF program. To get quicker payment terms through a hardship consideration, you will need to submit through the Beacon App.
Create Your Account Here (After Enrollment in the MTF): mfp.beaconchannelmanagement.com/
Below is additional information provided by NCPA at the 2025 Annual Convention regarding the MDPNP.
[NCPA What You Need to Know: Download PDF
For additional information on the Inflation Reduction Act, you can use the links above in this blog or visit the NCPA website for additional resources: ncpa.org/inflation-reduction-act-resources-and-advocacy
Update: September 08, 2025
CMS launched the Medicare Transaction Facilitator Data Module (MTF DM) on June 9, 2025, and has been working with dispensing entities across the U.S. to enroll and onboard since.
CMS is excited to announce that all 10 manufacturers for the Initial Price Applicability Year (IPAY) 2026 selected drugs have signaled their intent to use the Medicare Transaction Facilitator (MTF) Payment Module (PM). Enrollment into the MTF DM is necessary for dispensing entities in order to ensure dispensing entities receive any applicable Maximum Fair Price (MFP) refunds (when selected drugs are dispensed) via the MTF PM starting on January 1, 2026. CMS is in the process of reviewing the MFP Effectuation Plans submitted by each IPAY 2026 manufacturer and will be making versions of these plans available on the MTF DM in the near future; enroll in the MTF DM to ensure you have access to these plans!
CMS is committed to making sure all dispensing entities have the information and support needed to complete enrollment in the MTF DM. Enrollment ensures dispensing entities are prepared for the effectuation of the new negotiated MFPs for selected drugs covered under Medicare Part D beginning on January 1, 2026. In our continued efforts to provide supporting information to dispensing entities during the enrollment period, CMS is sharing the attached MTF DM Enrollment Toolkit. This toolkit provides information that dispensing entities and third-party support entities need to begin the enrollment process, and links to a host of other resources CMS has made available to support dispensing entity enrollment in the MTF DM. Don’t delay – review this toolkit and get started with your organization’s MTF enrollment today!
Help is Available: CMS has established a dedicated Help Desk to provide technical support throughout the enrollment process. The Help Desk is available from 7 AM to 7:30 PM EST, Monday – Friday, excluding federal holidays.
- Phone: 1-877-MTF-4HLP (1-877-683-4457)
- Help Desk website (Includes ticket submission and live chat features): mtf.helpdesk.cms.gov
Update: July 10th, 2025
Watch Independent Pharmacy Cooperative’s (IPC) exclusive informational webinar with representatives from the Centers for Medicare & Medicaid Services on the Medicare Transaction Facilitator (MTF) Enrollment for Dispensing Entities.
This webinar is an educational session designed to guide you through the process of enrolling as a Dispensing Entity in the Medicare Transaction Facilitator (MTF) program.
